GZN1201804). Authors contributions X.X., Q.L., and C.S. when ectopically expressed, can attenuate p53 activation-induced EGFR reduction and cellular senescence. We further showed that the improved degradation of DYRK1A caused by p53 activation was mediated by NMDA-IN-1 MDM2. MDM2 was found to literally interact with and ubiquitinate DYRK1A, ultimately leading to its proteosomal degradation. Importantly, administration… Continue reading GZN1201804)